Endocrine Abstracts

Introduction: Multiple endocrine neoplasia type 2A syndrome (MEN 2A) is caused by a germline mutation in the RET proto-oncogene and its phenotype includes medullary thyroid cancer, pheochromocytoma and primary hyperparathyroidism (PHPT). Parathyroid reimplantation in the sternocleidomastoid muscle or in the brachioradial muscle can be performed in case of intraoperative lesion of the parathyroid glands. In some cases, PHPT may occur due to the proliferation of autotransplanted...

IntroductionThe measurement of serum thyroglobulin (Tg), a glycoprotein produced exclusively by follicular thyroid cells, is an important tumour marker used in the follow-up of patients with differentiated thyroid carcinoma (DTC) and residual or recurrent disease. However, its role as a screening tool before thyroid surgery is not yet defined, as benign conditions can result in its increase.ObjectiveThe aim o...

Introduction: Chromogranin A continues to be one of the most valuable markers for neuroendocrine tumors (NETs) however, it has several limitations, including its reduced specificity.Methods: The authors present the case of a patient diagnosed with a midgut NET, during follow-up.Results: Male patient, 61 years old, with chronic renal disease (CRD), underwent right hemicolectomy owing to ileo-cecal valve lesion; hist...

Background: The identification of patients with high risk of diabetes mellitus (DM) after renal transplantation in the pre-transplantation period is crucial for the prevention of this pathology and reduction of the risk of cardiovascular morbidity and mortality. With this study we intended to identify the risk factors for NODAT in renal transplantation.Methods: All patients submitted to renal transplantation at Centro Hospitalar do Porto between 01/01/20...

Background: The identification of patients with NODAT in renal transplantation is essential to establish adequate treatment and to reduce cardiovascular risk and graft failure. With this study we intended to evaluate the frequency of NODAT and to characterize patients with NODAT in renal transplantation.Methods: All patients submitted to renal transplantation at Centro Hospitalar do Porto between 01/01/2009 and 12/31/2013 were retrospectively evaluated. ...

Introduction: Postpartum infarction of the anterior pituitary, known as Sheehan’s syndrome, is a rare cause of hypopituitarism. In many cases, the hormones deficiency is sequential which implies late diagnoses.Case Report 1: A 51-year-old woman was observed because her mother had medullary thyroid carcinoma. She had no evidence of endocrine neoplasia. Nevertheless, she was experiencing fatigue, hair loss and dry skin for several months. Her history ...

Introduction: Papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) are distinct neoplasms, associated with different histological findings. Their coexistence in the same patient is a rare event, requiring a different clinical approach.Clinical case: A 72-year-old patient with no family history of thyroid disease, underwent total thyroidectomy in February 2019, due to toxic multinodular goitre, with no evidence of postoperative complica...

Introduction: Type 1 gastric endocrine tumors (T1-GET) incidence is increasing world while mainly due to widespread use of upper endoscopy. Autoimmune disease (AID) is the hallmark of T1-GET, pernicious anemia is often found at presentation. Association with lymphocytic thyroiditis (LT) has been described.Aims: Retrospective evaluation of GET data from patients (pts) followed at IPO-Porto, including the presence of other AID with emphasis to LT.<p cl...

Introduction: Fine-needle biopsy(FNB) is an essential diagnostic tool in the evaluation of thyroid nodules, however, follicular neoplasm(FN) does not exclude malignancy. Some sonographic and cytological features have been described as being associated with increased risk of malignancy. The authors aimed to identify demographic, sonographic and cytologic features associated with malignancy in patients with a cytological diagnosis of FN.Methods: Descriptiv...

Introduction: Central diabetes insipidus (CDI) is characterized by a deficient secretion of anti-diuretic hormone (ADH), in which a large volume of hypotonic urine is eliminated. Pituitary metastatic disease is rare, accounting for 1% of all excised pituitary tumors and generally involves the posterior pituitary. Neoplasms that more often originate pituitary metastases are breast and lung cancer. Breast cancer (BC) is associated with pituitary secondary involvement in 5.3 to 2...